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信号转导蛋白9复合体7产抗体注意事项;This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
骨形态发生蛋白3抗体免 疫 原;KLH conjugated synthetic peptide derived from human MMP3: 301-400/472
羧基端小结构域磷酸酶1抗体注意事项;This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
粘蛋白/岩藻糖基转移酶3抗体免 疫 原;KLH conjugated synthetic peptide derived from human Blood Group Lewis b: 165-280/361
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