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激活素受体1B抗体
产物名称 | 英文名称 | 货号 |
激活素受体1B抗体 | ACVR1B | GOY-01K1894 |
商品属性:
英文名称: ACVR1B
中文名:激活素受体1B抗体
别 名;Activin A receptor
type 1B; Activin A receptor type II like kinase 4; Activin A type 1B receptor;
Activin A type IB receptor; Activin receptor like kinase 4; Activin receptor
type 1B; ACTR IB; ACTRIB; ACVR 1B; ACVRLK 4; ACVRLK4; ALK 4; ALK4;
Serine(threonine) protein kinase receptor R2; SKR 2; SKR2.
研究领域;肿瘤 免疫学 信号转导 转录调节因子 激酶和磷酸酶
抗体来源;Rabbit
克隆类型;Polyclonal
交叉反应;(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
产物应用;ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量;53kDa
细胞定位;细胞膜
性 状;Liquid
浓 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human Activin A Receptor Type IB:
301-400/505
亚 型;IgG
纯化方法;affinity
purified by Protein A
缓 冲 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项;This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Activins are dimeric growth and differentiation
factors which belong to the transforming growth factor beta (TGF beta)
superfamily of structurally related signaling proteins. Activins signal
through a heteromeric complex of receptor serine kinases which include at
least two type I (I and IB) and two type II (II and IIB) receptors. These
receptors are all transmembrane proteins, composed of a ligand binding
extracellular domain with a cysteine rich region, a transmembrane domain, and
a cytoplasmic domain with predicted serine/threonine specificity. Type I
receptors are essential for signaling, and type II receptors are required for
binding ligands and for expression of type I receptors. Transmembrane serine/threonine kinase activin
type-1 receptor forming an activin receptor complex with activin receptor
type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell
surface to the cytoplasm and is thus regulating a many physiological and
pathological processes including neuronal differentiation and neuronal
survival, hair follicle development and cycling, FSH production by the
pituitary gland, wound healing, extracellular matrix production,
immunosuppression and carcinogenesis. Activin is also thought to have a
paracrine or autocrine role in follicular development in the ovary. Within
the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a
primary activin receptors whereas the type-1 receptors like ACVR1B act as
downstream transducers of activin signals. Activin binds to type-2 receptor
at the plasma membrane and activates its serine-threonine kinase. The
activated receptor type-2 then phosphorylates and activates the type-1
receptor such as ACVR1B. Once activated, the type-1 receptor binds and
phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the
C-terminal tail. Soon after their association with the activin receptor and
subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm
where they interact with the common partner SMAD4. This SMAD complex
translocates into the nucleus where it mediates activin-induced
transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A,
can prevent the association of SMAD2 and SMAD3 with the activin receptor
complex, thereby blocking the activin signal. Activin signal transduction is
also antagonized by the binding to the receptor of inhibin-B via the IGSF1
inhibin coreceptor. ACVR1B also phosphorylates TDP2. |
多克隆抗体制备:
我公司合成抗原,保证阳性血清和抗体贰尝滨厂础效价达到1:32000,由蛋白抗原制备的多抗,保证奥叠检测结果是阳性。技术服务实行分步报价,按节点收费,为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行,我公司将为您的项目提供专业的建议。在制备过程中,与客户互动验证,确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时,也能满足客户抗体最终应用验证需求。技术服务实行分步报价,按节点收费,为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能,而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台,能为客户提供各种类型的重组抗体表达服务,包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达,抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务,如动物免疫、动物饲养、抗体修饰服务(如贵滨罢颁,贬搁笔等的标记)、以及贰尝滨厂础,奥叠,滨贬颁,顿叠等检测服务。
抗体定制服务:
已注册商标,主要用于抗体药物发现和开发,是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务,主要面向工业客户。
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