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去整合素样金属蛋白酶13抗体
产物名称 | 英文名称 | 货号 |
去整合素样金属蛋白酶13抗体 | ADAM13 | GOY-01K0764 |
商品属性：
英文名称: ADAM13
中文名:去整合素样金属蛋白酶13抗体
研究领域；细胞生物 神经生物学
抗体来源；Rabbit
克隆类型；Polyclonal
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；68kDa
细胞定位；细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from Xenopus (Silurana) tropicalis ADAM13:
701-800/911
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
ADAM13 was first described as a protein expressed
in somatic mesoderm and neural crest cells, in developing Xenopus embryos.
ADAM13 was also found in liver, heart, and intestines from adult Xenopus.
ADAM13 may regulate cellular signaling via Src and Src tyrosine kinase.
ADAM13 may also act as a cell attachment molecule, by binding integrins
through the cysteine rich domain amoung many other roles. A member of the
metalloproteinase family containing disintegrin like domains (ADAMs) the
functions of ADAM13 are still poorly understood. ADAM13 contains the
canonical HExxHxxxxxH zinc metalloproteinase motif, as well as disintegrin,
cysteine rich, EFG like, transmembrane and Cytoplasmic domains. ADAM13 has
been shown to be proteolytically active, cleaving fibronectin after binding
it to the EGF like domain. ADAM13 is also shed from cells in culture, cleaved
aminoterminal from the transmembrane domain, and is released into the culture
media. Shed ADAM13 is a 52 kD protein, and can form complexes with a2
macroglobulin, suggesting it is a competent protease. Xenopus ADAM13 has greatest
homology with human ADAM 33 (51% identical), and is 46% identical with human
or mouse ADAM12 or ADAM19. It is still unclear if any of these ADAMs are
species orthologs of Xenopus ADAM13, but there are significant differences
between the related sequences, suggesting that ADAM13 may be a unique
protein. The full length Xenopus ADAM13 sequence codes for a 914 amino acid
protein. Predicted mass is 99.749 kD, but glycosylation and cyteine rich
regions give Xenopus ADAM13 an apparent MW of 120 kD unprocessed, and 97 kD
processed forms, on reduced SDS PAGE gels. ADAM13 contains a putative furin
cleavage site, suggesting that a prohormone convertase cleaves the propeptide
domain away from the catalytic domain |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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