产物分类
Product Category相关文章
Related Articles详细介绍
肌动蛋白样蛋白6B抗体
产物名称 | 英文名称 | 货号 |
肌动蛋白样蛋白6B抗体 | BAF53b | GOY-01K1073 |
商品属性:
英文名称: BAF53b
中文名:肌动蛋白样蛋白6B抗体
别 名;53 kDa BRG1
associated factor B; ACL 6B; ACL6B; Actin like 6; Actin like protein 6B; Actin
like protein6B; Actin related protein; Actin related protein Baf53b; actin-like
6B; Actl 6; ACTL 6B; Actl6; ACTL6 B; ACTL6B; Arp Na; ArpN a; ArpN alpha; ArpNa;
ArpNalpha; Baf 53b; ACL6B_HUMAN.
研究领域;神经生物学 干细胞 表观遗传学
抗体来源;Rabbit
克隆类型;Polyclonal
交叉反应;(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产物应用;WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量;47kDa
细胞定位;细胞核
性 状;Liquid
浓 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human ACL6B: 301-400/426
亚 型;IgG
纯化方法;affinity
purified by Protein A
缓 冲 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项;This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
BAF53b is a member of a family of actin-related
proteins (ARPs), which shares significant sequence identity with conventional
actins. Both actins and ARPs comprise an actin fold, which forms an ATP
binding cleft. BAF53b is a component of the BAF (BRG/brm-associated factor)
complex in mammals, which is functionally related to the SWI/SNF complex in
S. cerevisiae and Drosophila, and is associated with chromatin remodelling to
facilitate transcriptional activation. As neural progenitors exit the cell
cycle, the highly homologous BAF53a subunit of the BAF complex is replaced by
BAF53b. This subunit switch is essential for the transition from from neural
stem cells / progenitors to postmitotic neurons. BAF53b also plays a role in
dendritic outgrowth, during which it is required to recruit the BAF complex
and the dendritic regulator CREST to specific gene promoters. This function
can not be performed by BAF53a. Belongs to the chromatin remodeling brain-specific
BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an
ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling
complex (nBAF complex) and is required for postmitotic neural development and
dendritic outgrowth. During neural development a switch from a stem/progenitor
to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the
cell cycle and become committed to their adult state. The transition from
proliferating neural stem/progenitor cells to post-mitotic neurons requires a
switch in subunit composition of the npBAF and nBAF complexes. As neural
progenitors exit mitosis and differentiate into neurons, npBAF complexes
which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous
alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in
neuron-specific complexes (nBAF). The npBAF complex is essential for the
self-renewal/proliferative capacity of the multipotent neural stem cells. The
nBAF complex along with CREST plays a role regulating the activity of genes
essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of
the nBAF complex but is required for targeting the complex and CREST to the
promoter of genes essential for dendritic growth (By similarity). |
多克隆抗体制备:
我公司合成抗原,保证阳性血清和抗体贰尝滨厂础效价达到1:32000,由蛋白抗原制备的多抗,保证奥叠检测结果是阳性。技术服务实行分步报价,按节点收费,为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行,我公司将为您的项目提供专业的建议。在制备过程中,与客户互动验证,确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时,也能满足客户抗体最终应用验证需求。技术服务实行分步报价,按节点收费,为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能,而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台,能为客户提供各种类型的重组抗体表达服务,包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达,抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务,如动物免疫、动物饲养、抗体修饰服务(如贵滨罢颁,贬搁笔等的标记)、以及贰尝滨厂础,奥叠,滨贬颁,顿叠等检测服务。
抗体定制服务:
已注册商标,主要用于抗体药物发现和开发,是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务,主要面向工业客户。
产物咨询
电话
微信扫一扫