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Bcl2相关抗凋亡基因6抗体
产物名称 | 英文名称 | 货号 |
Bcl2相关抗凋亡基因6抗体 | BAG6 | GOY-01K1620 |
商品属性:
英文名称: BAG6
中文名:Bcl2相关抗凋亡基因6抗体
别 名;family molecular chaperone regulator 6; BAG-6; BAG6; Bag6;
BAG6_HUMAN; BCL2-associated athanogene 6; D6S52E; G3; HLA B associated
transcript 3; HLA-B-associated transcript 3; Large proline-rich protein BAG6;
Protein G3; Protein Scythe.
研究领域;肿瘤 细胞生物 细胞凋亡
抗体来源;Rabbit
克隆类型;Polyclonal
交叉反应;(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产物应用;WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理论分子量;119kDa
细胞定位;细胞核 细胞浆 细胞外基质
性 状;Liquid
浓 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human BAT3/BAG6: 1042-1132/1132
亚 型;IgG
纯化方法;affinity
purified by Protein A
缓 冲 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件;Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项;This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Chaperone that plays a key role in various
processes such as apoptosis, insertion of tail-anchored (TA) membrane
proteins to the endoplasmic reticulum membrane and regulation of chromatin.
Acts in part by regulating stability of proteins and their degradation by the
proteasome. Participates in endoplasmic reticulum stress-induced apoptosis
via its interaction with AIFM1/AIF by regulating AIFM1/AIF stability and
preventing its degradation. Also required during spermatogenesis for synaptonemal
complex assembly via its interaction with HSPA2, by inhibiting
polyubiquitination and subsequent proteasomal degradation of HSPA2. Required
for selective ubiquitin-mediated degradation of defective nascent chain
polypeptides by the proteasome. In this context, may play a role in
immuno-proteasomes to generate antigenic peptides via targeted degradation,
thereby playing a role in antigen presentation in immune response. Key
component of the BAG6/BAT3 complex, a cytosolic multiprotein complex involved
in the post-translational delivery of tail-anchored (TA) membrane proteins to
the endoplasmic reticulum membrane. TA membrane proteins, also named type II
transmembrane proteins, contain a single C-terminal transmembrane region.
BAG6/BAT3 acts by facilitating TA membrane proteins capture by ASNA1/TRC40:
it is recruited to ribosomes synthesizing membrane proteins, interacts with
the transmembrane region of newly released TA proteins and transfers them to
ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane. Function: Serine-threonine kinase which transduces
inflammatory and cell-death signals (necroptosis) following death receptors
ligation, activation of pathogen recognition receptors (PRRs), and DNA
damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and
TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via
'Lys-63'-link chains acts as a critical enhancer of communication with
downstream signal transducers in the mitogen-activated protein kinase pathway
and the NF-kappa-B pathway, which in turn mediate downstream events including
the activation of genes encoding inflammatory molecules. Polyubiquitinated
protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a
critical event for NF-kappa-B activation. Interaction with other cellular
RHIM-containing adapters initiates gene activation and cell death. RIPK1 and
RIPK3 association, in particular, forms a necroptosis-inducing complex. |
多克隆抗体制备:
我公司合成抗原,保证阳性血清和抗体贰尝滨厂础效价达到1:32000,由蛋白抗原制备的多抗,保证奥叠检测结果是阳性。技术服务实行分步报价,按节点收费,为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行,我公司将为您的项目提供专业的建议。在制备过程中,与客户互动验证,确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时,也能满足客户抗体最终应用验证需求。技术服务实行分步报价,按节点收费,为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能,而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台,能为客户提供各种类型的重组抗体表达服务,包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达,抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务,如动物免疫、动物饲养、抗体修饰服务(如贵滨罢颁,贬搁笔等的标记)、以及贰尝滨厂础,奥叠,滨贬颁,顿叠等检测服务。
抗体定制服务:
已注册商标,主要用于抗体药物发现和开发,是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务,主要面向工业客户。
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