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肌动蛋白结合蛋白1抗体
产物名称 | 英文名称 | 货号 |
肌动蛋白结合蛋白1抗体 | ABLIM1 | GOY-01K0572 |
商品属性:
英文名称: ABLIM1
中文名:肌动蛋白结合蛋白1抗体
别 名;ABLIM 1; ABLIM;
abLIM-1; ABLIM-L; ABLIM-M; ABLIM-S; ABLIM1; ABLM1_HUMAN; Actin binding double
zinc finger protein; Actin binding LIM protein 1; Actin binding LIM protein
family member 1; Actin-binding double zinc finger protein; Actin-binding double
zinc finger protein; Actin-binding LIM protein 1; Actin-binding LIM protein
family member 1; DKFZp781D0148; FLJ14564; KIAA0059; LIM actin binding protein
1; LIMAB 1; LIMAB1; Limatin; RGD1565768; RP11-317F20.1.
研究领域;细胞生物 神经生物学 信号转导 细胞骨架 细胞外基质
抗体来源;Rabbit
克隆类型;Polyclonal
交叉反应;(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, )
产物应用;WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量;88kDa
细胞定位;细胞浆
性 状;Liquid
浓 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human ABLIM1: 681-778/778
亚 型;IgG
纯化方法;affinity
purified by Protein A
缓 冲 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项;This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
The C. elegans protein Unc-115 mediates axon
guidance by modulating the growth cone Actin cytoskeleton in response to
signals received by growth cone receptors. The mammalian homolog of Unc-115
is the Actin-binding LIM protein family member 1 (ABLIM1, also designated
Limatin). The ABLIM1 protein has an N-terminal domain that contains four
double zinc finger motifs, which conform to the LIM motif consensus sequence.
ABLIM1 binds to F-Actin through a dematin-like domain and is expressed in
retina, brain and muscle tissue. There are four known isoforms of ABLIM1. The
gene encoding ABLIM1 maps to a region of chromosome 10 associated with
frequent loss of heterozygosity in human tumors, thus identifying ABLIM1 as a
candidate tumor suppressor gene. ABLIM2 and ABLIM3 show highest expression in
muscle and neuronal tissues, bind to F-Actin, and are localized on stress fibers.
They also have been shown to enhance STARS (striated muscle activator of Rho
signaling) dependent activation of serum-response factor (SRF), thereby
modulating transcription. May act as scaffold protein (By similarity). May
play a role in the development of the retina. Has been suggested to play a
role in axon guidance. |
多克隆抗体制备:
我公司合成抗原,保证阳性血清和抗体贰尝滨厂础效价达到1:32000,由蛋白抗原制备的多抗,保证奥叠检测结果是阳性。技术服务实行分步报价,按节点收费,为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行,我公司将为您的项目提供专业的建议。在制备过程中,与客户互动验证,确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时,也能满足客户抗体最终应用验证需求。技术服务实行分步报价,按节点收费,为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能,而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台,能为客户提供各种类型的重组抗体表达服务,包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达,抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务,如动物免疫、动物饲养、抗体修饰服务(如贵滨罢颁,贬搁笔等的标记)、以及贰尝滨厂础,奥叠,滨贬颁,顿叠等检测服务。
抗体定制服务:
已注册商标,主要用于抗体药物发现和开发,是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务,主要面向工业客户。
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