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β淀粉样肽（1-40）抗体
产物名称 | 英文名称 | 货号 |
β淀粉样肽（1-40）抗体 | beta Amyloid 1-40 | GOY-01K0056 |
商品属性：
英文名称: beta Amyloid 1-40
中文名:β淀粉样肽（1-40）抗体
别 名；β-Amyloid 1-40;
beta Amyloid(1-40); beta-Amyloid 1-40; beta-Amyloid 1-40; Amyloid 1-40; A4;
AAA; ABETA; ABPP; AD1; Alzheimers Disease Amyloid Protein; Amyloid B; Amyloid
Beta A4 Protein Precursor; Amyloid Beta; Amyloid of Aging and Alzheimer
Disease; APP; APPI; B Amyloid; Beta APP; Cerebral Vascular Amyloid Peptide;
CTFgamma; CVAP; PN II; PN2; PreA4; Protease nexin II; A beta; A4_HUMAN.
研究领域；细胞生物 神经生物学 Alzheimer's
抗体来源；Mouse
克隆类型；Polyclonal
交叉反应；(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；4.4kDa
细胞定位；细胞核 细胞浆 细胞膜 细胞外基质
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide of human beta-Amyloid: 1-40/42
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
The cerebral and vascular plaques associated with
Alzheimer's disease are mainly composed of Amyloid beta peptides. beta
Amyloid is derived from cleavage of the Amyloid precursor protein and varies
in length from 39 to 43 amino acids. beta Amyloid [1-40], beta Amyloid
[1-42], and beta Amyloid [1-43] peptides result from cleavage of Amyloid
precursor protein after residues 40, 42, and 43, respectively. The cleavage
takes place by gamma-secretase during the last Amyloid precursor protein
processing step. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid
[1-43] peptides are major constituents of the plaques and tangles that occur
in Alzheimer's disease. beta Amyloid antibodies and peptides have been
developed as tools for elucidating the biology of Alzheimer's disease. Functions as a cell surface receptor and performs
physiological functions on the surface of neurons relevant to neurite growth,
neuronal adhesion and axonogenesis. Involved in cell mobility and
transcription regulation through protein-protein interactions. Can promote
transcription activation through binding to APBB1-KAT5 and inhibits Notch
signaling through interaction with Numb. Couples to apoptosis-inducing
pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase
activity. Acts as a kinesin I membrane receptor, mediating the axonal
transport of beta-secretase and presenilin 1. Involved in copper
homeostasis/oxidative stress through copper ion reduction. In vitro,
copper-metallated APP induces neuronal death directly or is potentiated
through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate
neurite outgrowth through binding to components of the extracellular matrix
such as heparin and collagen I and IV. The splice isoforms that contain the
BPTI domain possess protease inhibitor activity. Induces a AGER-dependent
pathway that involves activation of p38 MAPK, resulting in internalization of
amyloid-beta peptide and leading to mitochondrial dysfunction in cultured
cortical neurons. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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