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奥苍迟1信号通路蛋白1抗体
产物名称 | 英文名称 | 货号 |
Wnt1信号通路蛋白1抗体 | WISP1 | GOY-01K0192 |
商品属性：
英文名称: WISP1
中文名:Wnt1信号通路蛋白1抗体
别 名；CCN 4; CCN4; WISP
1; WISP 1c; WISP 1i; WISP 1tc; WISP1c; WISP1i; WISP1tc; WNT 1 induced secreted
protein 1; Wnt 1 induced secreted protein; WNT 1 inducible signaling pathway
protein 1; Wnt 1 signaling pathway protein 1; WNT1 induced secreted protein 1;
Wnt1 induced secreted protein; WNT1 inducible signaling pathway protein 1; Wnt1
signaling pathway protein 1; WISP1_HUMAN
研究领域；细胞生物 信号转导 干细胞 细胞凋亡 转录调节因子 表观遗传学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Rabbit, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；38kDa
细胞定位；分泌型蛋白
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human WISP1: 237-295/367
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
his gene encodes a member of the WNT1 inducible
signaling pathway (WISP) protein subfamily, which belongs to the connective
tissue growth factor (CTGF) family. WNT1 is a member of a family of
cysteine-rich, glycosylated signaling proteins that mediate diverse
developmental processes. The CTGF family members are characterized by four
conserved cysteine-rich domains: insulin-like growth factor-binding domain,
von Willebrand factor type C module, thrombospondin domain and C-terminal
cystine knot-like domain. This gene may be downstream in the WNT1 signaling
pathway that is relevant to malignant transformation. It is expressed at a
high level in fibroblast cells, and overexpressed in colon tumors. The
encoded protein binds to decorin and biglycan, two members of a family of
small leucine-rich proteoglycans present in the extracellular matrix of
connective tissue, and possibly prevents the inhibitory activity of decorin
and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis
in response to DNA damage through activation of the Akt kinase. It is 83%
identical to the mouse protein at the amino acid level. Multiple
alternatively spliced transcript variants have been identified. [provided by
RefSeq, Mar 2011]. Downstream regulator in the Wnt/Frizzled-signaling
pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in
response to DNA damage through activation of AKT kinase. Up-regulates the
anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In
vitro binding to skin fibroblasts occurs through the proteoglycans, decorin
and biglycan. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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