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甲状腺激素受体相互作用12抗体
产物名称 | 英文名称 | 货号 |
甲状腺激素受体相互作用12抗体 | TRIP12 | GOY-01K5225 |
商品属性：
英文名称: TRIP12
中文名:甲状腺激素受体相互作用12抗体
别 名；KIAA0045;
MGC138849; MGC138850; Thyroid hormone receptor interactor 12; Thyroid receptor
interacting protein 12; TRIP 12.
研究领域；细胞生物 表观遗传学 泛素
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；220kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human TRIP12: 61-160/1992
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This product
as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
TRIP12 (thyroid hormone receptor interactor 12) is
an ATP-dependent multisubunit protein that activates the proteolytic
activities of the multifunctional proteinase (20S proteasome) of the 26S
complex. TRP12 specifically interacts with the ligand binding domain of the
thyroid hormone receptor (in a thyroid hormone T3-independent manner) and
with retinoid X receptor (RXR). TRP12 was originally identified as a factor
that interacts with the thyroid hormone receptor. It was later found to also
interact with AAP-BP1, a component of the NEDD8 –activating enzyme, and function as an E3 ubiquitin
ligase for AAP-BP1. E3 ubiquitin-protein ligase involved in ubiquitin
fusion degradation (UFD) pathway and regulation of DNA repair. Part of the
ubiquitin fusion degradation (UFD) pathway, a process that mediates
ubiquitination of protein at their N-terminus, regardeless of the presence of
lysine residues in target proteins. In normal cells, mediates ubiquitination
and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor
suppressor required for p53/TP53 activation under oncogenic stress. In cancer
cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell
compartments, preventing isoform p19ARF/ARF ubiquitination and degradation.
Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also
catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation.
Ubiquitination and degradation of target proteins is regulated by interaction
with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction
between TRIP12 and target proteins. Acts as a key regulator of DNA damage
response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase
that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA
damage sites, thereby acting as a guard against excessive spreading of
ubiquitinated chromatin at damaged chromosomes. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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