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转运蛋白1抗体
产物名称 | 英文名称 | 货号 |
转运蛋白1抗体 | Transportin 1 | GOY-01K2211 |
商品属性：
英文名称: Transportin 1
中文名:转运蛋白1抗体
别 名；Importin 2;
Importin beta 2; IPO 2; IPO2; Karyopherin (importin) beta 2; Karyopherin beta
2; KPN B2; KPNB 2; KPNB2; M9 interacting protein; M9 region interacting
protein; M9 region interaction protein; M9-interacting protein; MIP 1; MIP;
MIP1; TNPO 1; TNPO1; Transportin 1; Transportin; Transportin-1; Transportin1;
TRN; TNPO1_HUMAN.
研究领域；细胞生物 免疫学 信号转导
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；102kDa
细胞定位；细胞核 细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Transportin 1: 1-100/898
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Transportin 1 is the beta subunit of the karyopherin
receptor complex which interacts with nuclear localization signals to target
proteins to the nucleus. The karyopherin receptor complex is a heterodimer of
an alpha subunit which recognizes the nuclear localization signal and a beta
subunit which docks the complex at nucleoporins. Alternate splicing of this
gene results in two transcript variants encoding different proteins. In cases
of HIV-1 infections, transportin 1 is known to bind and mediate the nuclear
import of HIV-1 Rev. Function: Functions in nuclear protein import as nuclear
transport receptor. Serves as receptor for nuclear localization signals (NLS)
in cargo substrates. Is thought to mediate docking of the importin/substrate
complex to the nuclear pore complex (NPC) through binding to nucleoporin and
the complex is subsequently translocated through the pore by an energy
requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran
binds to the importin, the importin/substrate complex dissociates and
importin is re-exported from the nucleus to the cytoplasm where GTP
hydrolysis releases Ran. The directionality of nuclear import is thought to
be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of
Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear
import of M9-containing proteins. In vitro, binds directly to the M9 region
of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and
mediates their nuclear import. Appears also to be involved in hnRNP A1/A2
nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A,
RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of
RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones,
and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import
of HIV-1 Rev. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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