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表皮生长因子样重复折迭1结构域蛋白3抗体
产物名称 | 英文名称 | 货号 |
表皮生长因子样重复折迭1结构域蛋白3抗体 | EDIL3 | GOY-01K0963 |
商品属性：
英文名称: EDIL3
中文名:表皮生长因子样重复折迭1结构域蛋白3抗体
别 名；DEL1;
Developmental endothelial locus 1; Developmentally regulated endothelial cell
locus 1 protein; EGF like repeat and discoidin I like domain containing protein
3; EGF like repeats and discoidin I like domains protein 3; Integrin binding
protein DEL1; EDIL3_HUMAN.
研究领域；心血管 细胞生物 神经生物学 信号转导 细胞粘附分子 内皮细胞 细胞骨架
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；52kDa
细胞定位；分泌型蛋白
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human EDIL3: 201-300/480
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
EDIL3 is an integrin ligand. It plays an important
role in mediating angiogenesis and may be important in vessel wall remodeling
and development. It also influences endothelial cell behavior.EGF-like repeat
and discoidin I-like domain-containing protein 3 (EDIL3; also Del-1 and
integrin-binding DEL1) is a 52 kDa extracellular matrix protein that is expressed
by endothelial tissues during embryonic vascular development. Human EDIL3 is
synthesized as a precursor with a 16 amino acid (aa) signal sequence and a
464 aa mature chain (SwissProt # O43854). The mature chain is composed of
three epidermal growth factor (EGF) repeats and two discoidin-I-like domains.
The second EGF repeat contains an RGD motif. Splicing variants produce two
isoforms for human EDIL3. Isoform 2 has an A -> G substitution at aa 66
and a deletion of aa 67-76 found in isoform 1. Mature human EDIL3 shares 96%
aa sequence identity with mature mouse EDIL3. The RGD motif of EDIL3 binds
alpha v beta 5 integrin, which, in turn, leads to increased angiogenic
transcription factor HoxD3 expression. HoxD3 activates alpha v beta 3 and
uPA, resulting in the transformation of resting endothelial cells to an
angiogenic state. EDIL3 becomes quiescent at the time of birth, and is no
longer expressed in normal adult tissues. It has been found, however,
re-expressed in a number of human tumors as well as in ischemic muscles and
ischemic brain tissue, which may play an important role in adult
angiogenesis. EDIL3 promotes adherence and migration of endothelial cells,
and acts as an endothelial cell survival agent through upregulation of Bcl-2
expression. Exogenous application of EDIL3 has been demonstrated to augment
angiogenesis and improve blood flow and tissue function in murine models of
hind-limb ischemia, cardiac ischemia and cerebral ischemia. EDIL3 has also
been shown to be an endogenous inhibitor of inflammatory cell recruitment by
interfering with the integrin LFA-1-dependent leukocyte-endothelial adhesion. Promotes adhesion of endothelial cells through
interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of
vascular-like structures. May be involved in regulation of vascular
morphogenesis of remodeling in embryonic development. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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