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胞吞再循环相关衔接蛋白颁贰狈罢叠1抗体
产物名称 | 英文名称 | 货号 |
胞吞再循环相关衔接蛋白CENTB1抗体 | CENTB1/ACAP1 | GOY-01K4663 |
商品属性：
英文名称: CENTB1/ACAP1
中文名:胞吞再循环相关衔接蛋白CENTB1抗体
别 名；ACAP 1; ACAP1;
ACAP1_HUMAN; ANK repeat and PH domain-containing protein 1; Arf GAP with coiled
coil ANK repeat and PH domains 1; Arf GAP with coiled coil, ankyrin repeat, and
pleckstrin homology domains 1; Arf-GAP with coiled-coil; Arf-GAP with
coiled-coil, ANK repeat and PH domain-containing protein 1; ArfGAP with
coiled-coil, ankyrin repeat and PH domains 1; CENT B1; Centaurin beta 1;
Centaurin-beta-1; CENTB 1; Cnt b1; Cnt-b1; Cntb1; KIAA0050.
研究领域；细胞生物 信号转导 细胞粘附分子
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Pig, Cow, Horse, Sheep, )
产物应用；WB=1:500-2000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；81kDa
细胞定位；细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CENTB1: 501-600/740
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
ACAP1 is a member of the ADP ribosylation factor
family of ARF6 GTPase-activating proteins (GAP). GAPs are important
regulators of Arf function by controlling the return of ARF to its inactive
state. ACAP1 is related to AGAP1 and ASAP1, and all three proteins are
similarly expressed in fibroblast cells such as NIH/3T3. Internalization and
recycling of integrin receptors is important in cell adhesion and migration
modulation, and once inside a cell, proteins and membranes are transported to
the endosome where they are sorted for recycling or degradation. ACAP1
promotes cargo sorting by associating directly to recycling cargo proteins.
Preventing this interaction inhibits protein recycling. ACAP1 binds
transferrin receptors, promoting their transport to the plasma membrane from
the endosome. Akt induced phosphorylation of ACAP1 at Ser 554 regulates ACAP1
interaction to integrin in endosomes, and downregulation of Akt or ACAP1 may
inhibit cell migration on Fibronectin. GTPase-activating protein (GAP) for ADP
ribosylation factor 6 (ARF6) required for clathrin-dependent export of
proteins from recycling endosomes to trans-Golgi network and cell surface. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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